Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells
Rutgers, The State University of New Jersey · Millennium Institute · +3 more institutions
Abstract
Although recent data suggests that osteoblasts play a key role within the hematopoietic stem cell (HSC) niche, the mechanisms underpinning this remain to be fully defined. The studies described herein examine the role in hematopoiesis of Osteopontin (Opn), a multidomain, phosphorylated glycoprotein, synthesized by osteoblasts, with well-described roles in cell adhesion, inflammatory responses, angiogenesis, and tumor metastasis. We demonstrate a previously unrecognized critical role for Opn in regulation of the physical location and proliferation of HSCs. Within marrow, Opn expression is restricted to the endosteal bone surface and contributes to HSC transmarrow migration toward the endosteal region, as…
Citation impact
- FWCI
- 18.46
- Percentile
- 100%
- References
- 58
Authors
10- SKSusan K. NilssonCorresponding
Rutgers, The State University of New Jersey, Millennium Institute, Cancer Institute of New South Wales, Westmead Institute, Rutgers Cancer Institute
- HMHayley M. Johnston
Rutgers, The State University of New Jersey, Millennium Institute, Cancer Institute of New South Wales, Westmead Institute, Rutgers Cancer Institute
- GWGenevieve Whitty
Rutgers, The State University of New Jersey, Millennium Institute, Cancer Institute of New South Wales, Westmead Institute, Rutgers Cancer Institute
- BWBrenda Williams
Rutgers, The State University of New Jersey, Millennium Institute, Cancer Institute of New South Wales, Westmead Institute, Rutgers Cancer Institute
- RJRyan J. Webb
Rutgers, The State University of New Jersey, Millennium Institute, Cancer Institute of New South Wales, Westmead Institute, Rutgers Cancer Institute
Topics & keywords
- Osteopontin
- Cell biology
- Haematopoiesis
- Stem cell
- Biology
- Progenitor cell
- Hematopoietic stem cell
- Integrin