Oxidative Stress, Mitochondrial Dysfunction, and Aging
University of Massachusetts Chan Medical School
Abstract
Aging is an intricate phenomenon characterized by progressive decline in physiological functions and increase in mortality that is often accompanied by many pathological diseases. Although aging is almost universally conserved among all organisms, the underlying molecular mechanisms of aging remain largely elusive. Many theories of aging have been proposed, including the free-radical and mitochondrial theories of aging. Both theories speculate that cumulative damage to mitochondria and mitochondrial DNA (mtDNA) caused by reactive oxygen species (ROS) is one of the causes of aging. Oxidative damage affects replication and transcription of mtDNA and results in a decline in mitochondrial function which in turn…
Citation impact
- FWCI
- 11.44
- Percentile
- 100%
- References
- 234
Authors
3Topics & keywords
- Mitochondrial DNA
- Oxidative stress
- Mitochondrion
- Oxidative damage
- Reactive oxygen species
- Senescence
- DNA damage
- Ageing
- Good health and well-being