Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells
Research Institute of Radiology · Richard L. Roudebush VA Medical Center · +1 more institution
Abstract
BACKGROUND: The delivery of autologous cells to increase angiogenesis is emerging as a treatment option for patients with cardiovascular disease but may be limited by the accessibility of sufficient cell numbers. The beneficial effects of delivered cells appear to be related to their pluripotency and ability to secrete growth factors. We examined nonadipocyte stromal cells from human subcutaneous fat as a novel source of therapeutic cells. METHODS AND RESULTS: Adipose stromal cells (ASCs) were isolated from human subcutaneous adipose tissue and characterized by flow cytometry. ASCs secreted 1203+/-254 pg of vascular endothelial growth factor (VEGF) per 10(6) cells, 12 280+/-2944 pg of hepatocyte growth factor…
Citation impact
- FWCI
- 21.83
- Percentile
- 100%
- References
- 30
Authors
10- JRJalees RehmanCorresponding
Research Institute of Radiology, Richard L. Roudebush VA Medical Center, Indiana University – Purdue University Indianapolis
- DODmitry O. Traktuev
Research Institute of Radiology, Richard L. Roudebush VA Medical Center, Indiana University – Purdue University Indianapolis
- JLJingling Li
Research Institute of Radiology, Richard L. Roudebush VA Medical Center, Indiana University – Purdue University Indianapolis
- SMStephanie Merfeld‐Clauss
Research Institute of Radiology, Richard L. Roudebush VA Medical Center, Indiana University – Purdue University Indianapolis
- CJConstance J. Temm‐Grove
Research Institute of Radiology, Richard L. Roudebush VA Medical Center, Indiana University – Purdue University Indianapolis
Topics & keywords
- Stromal cell
- Adipose tissue
- Angiogenesis
- Vascular endothelial growth factor
- Hepatocyte growth factor
- Medicine
- Growth factor
- Mesenchymal stem cell
- Good health and well-being