Enhanced Chemotherapy Efficacy by Sequential Delivery of siRNA and Anticancer Drugs Using PEI‐Grafted Graphene Oxide

Loading and delivery of Bcl-2-targeted short interfering RNA (siRNA) and anticancer drug doxorubicin (DOX) by polyethylenimine (PEI)-conjugated graphene oxide (PEI-GO) is studied. A higher knockdown efficiency of siRNA delivered by PEI-GO than by PEI is achieved. Sequential delivery of siRNA and DOX by the PEI-GO nanocarrier shows a synergistic effect, which leads to significantly improved chemotherapy efficacy. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any…