reviewThe FASEB JournalAug 1, 2002Closed access

Cellular adaptation to hypoxia: O 2 ‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O 2 ‐regulated gene expression

RHRoland H. Wenger

Leipzig University

PubMed
Indexed incrossrefpubmed

Abstract

ABSTRACT Although it was known for a long time that oxygen deprivation leads to the transcriptional induction of the gene encoding erythropoietin, the molecular mechanisms behind this process remained enigmatic. The cloning of the hypoxia‐inducible factors (HIFs), the finding that HIF‐1 regulates the expression of many more genes apart from erythropoietin, and the elucidation of the oxygen‐dependent mechanisms degrading the HIF a subunits recently led to the spectacular discovery of the molecular principles of oxygen sensing. This review aims to summarize our current knowledge of oxygen‐regulated gene expression.—Wenger, R. H. Cellular adaptation to hypoxia: O 2 ‐sensing protein hydroxylases, hypoxia‐inducible…

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1,123
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FWCI
32.08
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100%
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Authors

1

Topics & keywords

Topics
Keywords
  • Gene
  • Transcription factor
  • Gene expression
  • Transcription (linguistics)
  • Hypoxia (environmental)
  • Biology
  • Erythropoietin
  • Cell biology
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