Farnesoid X receptor antagonizes nuclear factor κB in hepatic inflammatory response
City Of Hope National Medical Center · GTx (United States)
Abstract
The farnesoid X receptor (FXR) is a nuclear receptor that plays key roles in hepatoprotection by maintaining the homeostasis of liver metabolism. FXR null mice display strong hepatic inflammation and develop spontaneous liver tumors. In this report, we demonstrate that FXR is a negative modulator of nuclear factor kappaB (NF-kappaB)-mediated hepatic inflammation. Activation of FXR by its agonist ligands inhibited the expression of inflammatory mediators in response to NF-kappaB activation in both HepG2 cells and primary hepatocytes cultured in vitro. In vivo, compared with wild-type controls, FXR(-/-) mice displayed elevated messenger RNA (mRNA) levels of inducible nitric oxide synthase (iNOS),…
Citation impact
- FWCI
- 8.33
- Percentile
- 100%
- References
- 52
Authors
6Topics & keywords
- Farnesoid X receptor
- Nuclear receptor
- Chemistry
- Receptor
- Internal medicine
- Endocrinology
- Medicine
- Transcription factor
- Good health and well-being