Aging and DNA methylation
Beckman Research Institute · Van Andel Institute
Indexed incrossrefdoajpubmed
Abstract
In this Opinion article, we summarize how changes in DNA methylation occur during aging in mammals and discuss examples of how such events may contribute to the aging process. We explore mechanisms that could facilitate DNA methylation changes in a site-specific manner and highlight a model in which region-specific DNA hypermethylation during aging is facilitated in a competitive manner by destabilization of the Polycomb repressive complex.
Citation impact
568
total citations
- FWCI
- 27.10
- Percentile
- 100%
- References
- 98
Citations per year
Authors
2Topics & keywords
Keywords
- Biology
- DNA methylation
- DNA
- Methylation
- Epigenetics
- Genetics
- Computational biology
- Gene
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