450K Epigenome-Wide Scan Identifies Differential DNA Methylation in Newborns Related to Maternal Smoking during Pregnancy
National Institutes of Health · National Institute of Environmental Health Sciences · +6 more institutions
Abstract
Epigenetic modifications, such as DNA methylation, due to in utero exposures may play a critical role in early programming for childhood and adult illness. Maternal smoking is a major risk factor for multiple adverse health outcomes in children, but the underlying mechanisms are unclear.
We investigated epigenome-wide methylation in cord blood of newborns in relation to maternal smoking during pregnancy.
Citation impact
- FWCI
- 31.30
- Percentile
- 100%
- References
- 40
Authors
16- BRBonnie R. JoubertCorresponding
National Institutes of Health, National Institute of Environmental Health Sciences
- SESiri E. Håberg
Norwegian Institute of Public Health
- RMRoy M. Nilsen
Haukeland University Hospital
- XWXuting Wang
National Institutes of Health, National Institute of Environmental Health Sciences
- SEStein E. Vollset
Norwegian Institute of Public Health, University of Bergen
Topics & keywords
- DNA methylation
- Epigenome
- Epigenetics
- Pregnancy
- Methylation
- CpG site
- Biomarker
- Cohort
- Good health and well-being
Funding
- NFNorges ForskningsrådAward: 151918/S10
- NINational Institutes of HealthAwards: UO1 NS 047537-01, R01DK085173, NO-ES-75558, P30ES011961, R01ES016772
- NINational Institute of Neurological Disorders and StrokeAwards: 047537-01, 1 UO1 NS 047537-01, UO1 NS 047537-01, UO1 NS 047537
- NINational Institute of Environmental Health SciencesAwards: UO1 NS 047537-01, NO-ES-75558, R01ES016772, P30ES011961