Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
The University of Texas MD Anderson Cancer Center · The University of Texas Health Science Center at Houston · +3 more institutions
Abstract
How organ size is controlled in mammals is not currently understood. In Drosophila the Hippo signaling pathway functions to suppress growth in imaginal discs and has been suggested to control organ size. To investigate the role of hippo signaling in regulation of mammalian organ size we have generated conditional alleles of Sav1, mst1, and mst2, orthologs of Drosophila Salvador and hippo, respectively. Specific deletion of both mst1 and mst2 in hepatocytes results in significantly enlarged livers due to excessive proliferation. By the age of 5-6 months, mst1/2 conditional mutant livers have multiple foci of liver tumors, indicating that the combined activities of mst1 and mst2 act as redundant tumor…
Citation impact
- FWCI
- 22.69
- Percentile
- 100%
- References
- 40
Authors
11- LLLi LuCorresponding
The University of Texas MD Anderson Cancer Center, The University of Texas Health Science Center at Houston
- YLYing Li
The University of Texas MD Anderson Cancer Center, The University of Texas at Austin, The University of Texas Health Science Center at Houston
- SMSoo Mi Kim
The University of Texas MD Anderson Cancer Center
- WBWouter Bossuyt
The University of Texas MD Anderson Cancer Center
- PLPu Liu
The University of Texas MD Anderson Cancer Center, The University of Texas at Austin, The University of Texas Health Science Center at Houston
Topics & keywords
- Hippo signaling pathway
- Biology
- Cell biology
- Mutant
- Suppressor
- Merlin (protein)
- Signal transduction
- Cancer research
- Good health and well-being