Proline Mechanisms of Stress Survival
University of Nebraska–Lincoln · Nutrition Sciences (Belgium)
Abstract
SIGNIFICANCE: The imino acid proline is utilized by different organisms to offset cellular imbalances caused by environmental stress. The wide use in nature of proline as a stress adaptor molecule indicates that proline has a fundamental biological role in stress response. Understanding the mechanisms by which proline enhances abiotic/biotic stress response will facilitate agricultural crop research and improve human health. RECENT ADVANCES: It is now recognized that proline metabolism propels cellular signaling processes that promote cellular apoptosis or survival. Studies have shown that proline metabolism influences signaling pathways by increasing reactive oxygen species (ROS) formation in the mitochondria…
Citation impact
- FWCI
- 8.36
- Percentile
- 100%
- References
- 160
Authors
4Topics & keywords
- Proline dehydrogenase
- Proline
- Cell biology
- Biology
- Signal transduction
- Reactive oxygen species
- Biochemistry
- Cell signaling
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