Whole-Genome Analysis of Histone H3 Lysine 27 Trimethylation in Arabidopsis

Trimethylation of histone H3 lysine 27 (H3K27me3) plays critical roles in regulating animal development, and in several cases, H3K27me3 is also required for the proper expression of developmentally important genes in plants. However, the extent to which H3K27me3 regulates plant genes on a genome-wide scale remains unknown. In addition, it is not clear whether the establishment and spreading of H3K27me3 occur through the same mechanisms in plants and animals. We identified regions containing H3K27me3 in the genome of the flowering plant Arabidopsis thaliana using a high-density whole-genome tiling microarray. The results suggest that H3K27me3 is a major silencing mechanism in plants that regulates an…

• HH
  Howard Hughes Medical Institute
• DF
  Deutsche Forschungsgemeinschaft
• NI
  National Institutes of Health

  Awards: GM07104, grant GM60398, GM60398
• UP
  U.S. Public Health Service
• BA
  Biotechnology and Biological Sciences Research Council
• JC
  Jonsson Cancer Center Foundation