reviewBloodDec 22, 2012GREEN OA

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

DJDominik J. SchaerPWPaul W. BuehlerAIAbdu I. AlayashJDJohn D. BelcherGMGregory M. Vercellotti

University Hospital of Zurich · Center for Biologics Evaluation and Research · +1 more institution

PubMed
Indexed incrossrefdatacitepubmed

Abstract

Hemolysis occurs in many hematologic and nonhematologic diseases. Extracellular hemoglobin (Hb) has been found to trigger specific pathophysiologies that are associated with adverse clinical outcomes in patients with hemolysis, such as acute and chronic vascular disease, inflammation, thrombosis, and renal impairment. Among the molecular characteristics of extracellular Hb, translocation of the molecule into the extravascular space, oxidative and nitric oxide reactions, hemin release, and molecular signaling effects of hemin appear to be the most critical. Limited clinical experience with a plasma-derived haptoglobin (Hp) product in Japan and more recent preclinical animal studies suggest that the natural Hb…

Citation impact

745
total citations
FWCI
15.89
Percentile
100%
References
103
Citations per year

Authors

5

Topics & keywords

Topics
Keywords
  • Hemopexin
  • Hemin
  • Hemolysis
  • Haptoglobin
  • Hemoglobin
  • Sepsis
  • Medicine
  • Immunology
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