reviewBiopolymersSep 25, 2007Closed access

Protein secondary structure analyses from circular dichroism spectroscopy: Methods and reference databases

LWLee WhitmoreBWB.A. Wallace

Birkbeck, University of London

PubMed
Indexed incrossrefpubmed

Abstract

Abstract Circular dichroism (CD) spectroscopy has been a valuable method for the analysis of protein secondary structures for many years. With the advent of synchrotron radiation circular dichroism (SRCD) and improvements in instrumentation for conventional CD, lower wavelength data are obtainable and the information content of the spectra increased. In addition, new computation and bioinformatics methods have been developed and new reference databases have been created, which greatly improve and facilitate the analyses of CD spectra. This article discusses recent developments in the analysis of protein secondary structures, including features of the DICHROWEB analysis webserver. © 2007 Wiley Periodicals, Inc.…

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Authors

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Topics & keywords

Topics
Keywords
  • Circular dichroism
  • Chemistry
  • Protein secondary structure
  • Spectroscopy
  • Synchrotron radiation
  • Preprint
  • Crystallography
  • Database
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