articleJournal of Nucleic AcidsJan 1, 2010GOLD OA

Molecular Mechanisms of Ultraviolet Radiation‐Induced DNA Damage and Repair

RPRajesh P. RastogiRRRicha RichaAKAshok KumarMBMadhu B. TyagiRPRajeshwar P. Sinha

Banaras Hindu University

PubMed
Indexed incrossrefdoajpubmed

Abstract

DNA is one of the prime molecules, and its stability is of utmost importance for proper functioning and existence of all living systems. Genotoxic chemicals and radiations exert adverse effects on genome stability. Ultraviolet radiation (UVR) (mainly UV-B: 280-315 nm) is one of the powerful agents that can alter the normal state of life by inducing a variety of mutagenic and cytotoxic DNA lesions such as cyclobutane-pyrimidine dimers (CPDs), 6-4 photoproducts (6-4PPs), and their Dewar valence isomers as well as DNA strand breaks by interfering the genome integrity. To counteract these lesions, organisms have developed a number of highly conserved repair mechanisms such as photoreactivation, base excision…

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Topics & keywords

Topics
Keywords
  • DNA repair
  • Photolyase
  • Pyrimidine dimer
  • Nucleotide excision repair
  • DNA damage
  • Homologous recombination
  • DNA
  • Base excision repair
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