Nano neuro knitting: Peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision

Nanotechnology is often associated with materials fabrication, microelectronics, and microfluidics. Until now, the use of nanotechnology and molecular self assembly in biomedicine to repair injured brain structures has not been explored. To achieve axonal regeneration after injury in the CNS, several formidable barriers must be overcome, such as scar tissue formation after tissue injury, gaps in nervous tissue formed during phagocytosis of dying cells after injury, and the failure of many adult neurons to initiate axonal extension. Using the mammalian visual system as a model, we report that a designed self-assembling peptide nanofiber scaffold creates a permissive environment for axons not only to regenerate…

• MI
  Massachusetts Institute of Technology
• UO
  University of Hong Kong
• DC
  Deshpande Center for Technological Innovation, Massachusetts Institute of Technology