VISTA: computational tools for comparative genomics

Comparison of DNA sequences from different species is a fundamental method for identifying functional elements in genomes. Here, we describe the VISTA family of tools created to assist biologists in carrying out this task. Our first VISTA server at http://www-gsd.lbl.gov/vista/ was launched in the summer of 2000 and was designed to align long genomic sequences and visualize these alignments with associated functional annotations. Currently the VISTA site includes multiple comparative genomics tools and provides users with rich capabilities to browse pre-computed whole-genome alignments of large vertebrate genomes and other groups of organisms with VISTA Browser, to submit their own sequences of interest to…

• UD
  U.S. Department of Energy
• NI
  National Institutes of Health
• OO
  Office of Science
• NH
  National Heart, Lung, and Blood Institute
• BA
  Biological and Environmental Research
• LB
  Lawrence Berkeley National Laboratory