Coronavirus Main Proteinase (3CL pro ) Structure: Basis for Design of Anti-SARS Drugs
Institute of Molecular Biotechnology · University of Würzburg · +3 more institutions
Abstract
A novel coronavirus has been identified as the causative agent of severe acute respiratory syndrome (SARS). The viral main proteinase (Mpro, also called 3CLpro), which controls the activities of the coronavirus replication complex, is an attractive target for therapy. We determined crystal structures for human coronavirus (strain 229E) Mpro and for an inhibitor complex of porcine coronavirus [transmissible gastroenteritis virus (TGEV)] Mpro, and we constructed a homology model for SARS coronavirus (SARS-CoV) Mpro. The structures reveal a remarkable degree of conservation of the substrate-binding sites, which is further supported by recombinant SARS-CoV Mpro-mediated cleavage of a TGEV Mpro substrate. Molecular…
Citation impact
- FWCI
- 41.46
- Percentile
- 100%
- References
- 15
Authors
5- KAK. AnandCorresponding
Institute of Molecular Biotechnology, University of Würzburg, Jena University Hospital, Friedrich Schiller University Jena, University of Lübeck
- JZJohn ZiebuhrCorresponding
Institute of Molecular Biotechnology, University of Würzburg, Jena University Hospital, Friedrich Schiller University Jena, University of Lübeck
- PWParvesh Wadhwani
Institute of Molecular Biotechnology, University of Würzburg, Jena University Hospital, Friedrich Schiller University Jena, University of Lübeck
- JMJ.R. Mesters
Institute of Molecular Biotechnology, University of Würzburg, Jena University Hospital, Friedrich Schiller University Jena, University of Lübeck
- RHR. HilgenfeldCorresponding
Institute of Molecular Biotechnology, University of Würzburg, Jena University Hospital, Friedrich Schiller University Jena, University of Lübeck
Topics & keywords
- Coronavirus disease 2019 (COVID-19)
- Coronavirus
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- 2019-20 coronavirus outbreak
- Virology
- Severe acute respiratory syndrome coronavirus
- Computational biology
- Biology