articleStatistics in MedicineDec 7, 2004BRONZE OA

An experimental design for the development of adaptive treatment strategies

SASusan A. Murphy

University of Michigan · Institute for Social Research

PubMed
Indexed incrossrefpubmed

Abstract

In adaptive treatment strategies, the treatment level and type is repeatedly adjusted according to ongoing individual response. Since past treatment may have delayed effects, the development of these treatment strategies is challenging. This paper advocates the use of sequential multiple assignment randomized trials in the development of adaptive treatment strategies. Both a simple ad hoc method for ascertaining sample sizes and simple analysis methods are provided.

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740
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Topics & keywords

Topics
Keywords
  • Computer science
  • Simple (philosophy)
  • Adaptive design
  • Sample size determination
  • Post hoc
  • Adaptive strategies
  • Treatment effect
  • Clinical trial
UN Sustainable Development Goals
  • Good health and well-being
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