Insights Into the Role of the Microbiome in Obesity and Type 2 Diabetes
Amsterdam UMC Location University of Amsterdam · University of Amsterdam · +3 more institutions
Abstract
The worldwide prevalence of obesity and type 2 diabetes mellitus (T2DM) continues to rise at an alarming pace. Recently the potential role of the gut microbiome in these metabolic disorders has been identified. Obesity is associated with changes in the composition of the intestinal microbiota, and the obese microbiome seems to be more efficient in harvesting energy from the diet. Lean male donor fecal microbiota transplantation (FMT) in males with metabolic syndrome resulted in a significant improvement in insulin sensitivity in conjunction with an increased intestinal microbial diversity, including a distinct increase in butyrate-producing bacterial strains. Such differences in gut microbiota composition…
Citation impact
- FWCI
- 21.05
- Percentile
- 100%
- References
- 75
Authors
4- AVAnnick V. Hartstra
Amsterdam UMC Location University of Amsterdam, University of Amsterdam
- KEKristien E. Bouter
Amsterdam UMC Location University of Amsterdam, University of Amsterdam
- FBFredrik Bäckhed
University of Copenhagen, Novo Nordisk Foundation, University of Gothenburg
- MNMax NieuwdorpCorresponding
Amsterdam UMC Location University of Amsterdam, University of Gothenburg, University of Amsterdam
Topics & keywords
- Butyrate
- Gut flora
- Microbiome
- Medicine
- Obesity
- Type 2 diabetes
- Metabolic syndrome
- Type 2 Diabetes Mellitus
- Good health and well-being