Enteric dysbiosis associated with a mouse model of alcoholic liver disease

UNLABELLED: The translocation of bacteria and bacterial products into the circulation contributes to alcoholic liver disease. Intestinal bacterial overgrowth is common in patients with alcoholic liver disease. The aims of our study were to investigate bacterial translocation, changes in the enteric microbiome, and its regulation by mucosal antimicrobial proteins in alcoholic liver disease. We used a mouse model of continuous intragastric feeding of alcohol or an isocaloric diet. Bacterial translocation occurred prior to changes observed in the microbiome. Quantitative changes in the intestinal microflora of these animals were assessed first using conventional culture techniques in the small and large…

• UO
  University of Southern California
• NI
  National Institutes of Health

  Awards: K08 DK081830, P50AA11999
• NI
  National Institute on Alcohol Abuse and Alcoholism

  Award: P50AA11999