Conditioned pain modulation predicts duloxetine efficacy in painful diabetic neuropathy
Rambam Health Care Campus · Technion – Israel Institute of Technology · +1 more institution
Abstract
This study aims to individualize the selection of drugs for neuropathic pain by examining the potential coupling of a given drug's mechanism of action with the patient's pain modulation pattern. The latter is assessed by the conditioned pain modulation (CPM) and temporal summation (TS) protocols. We hypothesized that patients with a malfunctioning pain modulation pattern, such as less efficient CPM, would benefit more from drugs augmenting descending inhibitory pain control than would patients with a normal modulation pattern of efficient CPM. Thirty patients with painful diabetic neuropathy received 1 week of placebo, 1 week of 30 mg/d duloxetine, and 4 weeks of 60 mg/d duloxetine. Pain modulation was…
Citation impact
- FWCI
- 19.80
- Percentile
- 100%
- References
- 36
Authors
5- DYDavid YarnitskyCorresponding
Rambam Health Care Campus, Technion – Israel Institute of Technology
- MGMichal Granot
University of Haifa
- HNHadas Nahman‐Averbuch
Technion – Israel Institute of Technology
- MKMogher Khamaisi
Rambam Health Care Campus
- YGYelena Granovsky
Technion – Israel Institute of Technology, Rambam Health Care Campus
Topics & keywords
- Duloxetine
- Medicine
- Diabetic neuropathy
- Duloxetine Hydrochloride
- Anesthesia
- Diabetes mellitus
- Endocrinology
- Alternative medicine
- Good health and well-being