UV Radiation and the Skin
The Graduate Center, CUNY · University of Kentucky · +1 more institution
Abstract
UV radiation (UV) is classified as a "complete carcinogen" because it is both a mutagen and a non-specific damaging agent and has properties of both a tumor initiator and a tumor promoter. In environmental abundance, UV is the most important modifiable risk factor for skin cancer and many other environmentally-influenced skin disorders. However, UV also benefits human health by mediating natural synthesis of vitamin D and endorphins in the skin, therefore UV has complex and mixed effects on human health. Nonetheless, excessive exposure to UV carries profound health risks, including atrophy, pigmentary changes, wrinkling and malignancy. UV is epidemiologically and molecularly linked to the three most common…
Citation impact
- FWCI
- 33.65
- Percentile
- 100%
- References
- 230
Authors
4- JAJohn A. D’OrazioCorresponding
The Graduate Center, CUNY, University of Kentucky, Markey Cancer Center
- SGStuart G. Jarrett
University of Kentucky, Markey Cancer Center
- AAAlexandra Amaro-Ortiz
The Graduate Center, CUNY, University of Kentucky
- TSTimothy Scott
The Graduate Center, CUNY, University of Kentucky
Topics & keywords
- Skin cancer
- Melanocortin 1 receptor
- Basal cell carcinoma
- Carcinogen
- Human skin
- Melanin
- Cancer research
- Melanoma
- Good health and well-being