Independently Evolved Virulence Effectors Converge onto Hubs in a Plant Immune System Network
University of North Carolina at Chapel Hill · Centre National de la Recherche Scientifique · +11 more institutions
Abstract
Plants generate effective responses to infection by recognizing both conserved and variable pathogen-encoded molecules. Pathogens deploy virulence effector proteins into host cells, where they interact physically with host proteins to modulate defense. We generated an interaction network of plant-pathogen effectors from two pathogens spanning the eukaryote-eubacteria divergence, three classes of Arabidopsis immune system proteins, and ~8000 other Arabidopsis proteins. We noted convergence of effectors onto highly interconnected host proteins and indirect, rather than direct, connections between effectors and plant immune receptors. We demonstrated plant immune system functions for 15 of 17 tested host proteins…
Citation impact
- FWCI
- 85.48
- Percentile
- 100%
- References
- 35
Authors
34- MSM. Shahid MukhtarCorresponding
University of North Carolina at Chapel Hill
- ACAnne‐Ruxandra CarvunisCorresponding
Centre National de la Recherche Scientifique, Harvard University, Dana-Farber Cancer Institute, Translational Innovation in Medicine and Complexity, Université Grenoble Alpes
- MDMatija DrezeCorresponding
Harvard University, University of Namur, Dana-Farber Cancer Institute
- PEPetra EppleCorresponding
University of North Carolina at Chapel Hill
- JSJens Steinbrenner
University of Warwick
Topics & keywords
- Virulence
- Effector
- Immune system
- Biology
- Computational biology
- Computer science
- Genetics
- Cell biology
- Responsible consumption and production