Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways
National Institutes of Health · Max Planck Institute for Metabolism Research · +14 more institutions
Abstract
Gene-expression profiling has been used to define 3 molecular subtypes of diffuse large B-cell lymphoma (DLBCL), termed germinal center B-cell-like (GCB) DLBCL, activated B-cell-like (ABC) DLBCL, and primary mediastinal B-cell lymphoma (PMBL). To investigate whether these DLBCL subtypes arise by distinct pathogenetic mechanisms, we analyzed 203 DLBCL biopsy samples by high-resolution, genome-wide copy number analysis coupled with gene-expression profiling. Of 272 recurrent chromosomal aberrations that were associated with gene-expression alterations, 30 were used differentially by the DLBCL subtypes (P
Citation impact
- FWCI
- 27.87
- Percentile
- 100%
- References
- 38
Authors
25- GLGeorg Lenz
National Institutes of Health, Max Planck Institute for Metabolism Research
- GWGeorge W. Wright
National Institutes of Health
- NCN. C. Tolga Emre
National Institutes of Health, Max Planck Institute for Metabolism Research
- HKHolger Kohlhammer
National Institutes of Health, Max Planck Institute for Metabolism Research
- SSSandeep S. Davé
National Institutes of Health, Max Planck Institute for Metabolism Research
Topics & keywords
- Diffuse large B-cell lymphoma
- Biology
- Cancer research
- Germinal center
- Gene expression profiling
- Amplicon
- Lymphoma
- Gene knockdown
- Good health and well-being