Dialysis Dose and Intradialytic Hypotension: Results from the HEMO Study

<b><i>Background:</i></b> Intradialytic hypotension (IDH) is common and is associated with increased morbidity and mortality in chronic hemodialysis patients. A higher dialysis ‘dose' may generate transient intradialytic osmotic gradients, predisposing to intracellular fluid shifts and resulting in hypotension. <b><i>Study Design:</i></b> We performed a post hoc analysis of the HEMO study, a multicenter trial that randomized chronic hemodialysis patients to high versus standard Kt/V and higher versus lower membrane flux. In order to achieve dose targets, per protocol, adjustments were made in membrane efficiency, blood flow or dialysate flow before changing…

• AS
  American Society of Nephrology
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases