A Photostable AIE Luminogen for Specific Mitochondrial Imaging and Tracking
Hong Kong University of Science and Technology · Institute of Molecular Functional Materials · +2 more institutions
Abstract
Tracking the dynamics of mitochondrial morphology has attracted much research interest because of its involvement in early stage apoptosis and degenerative conditions. To follow this process, highly specific and photostable fluorescent probes are in demand. Commercially available mitochondria trackers, however, suffer from poor photostability. To overcome this limitation, we have designed and synthesized a fluorescent agent, tetraphenylethene-triphenylphosphonium (TPE-TPP), for mitochondrial imaging. Inherent from the mitochondrial-targeting ability of TPP groups and the aggregation-induced emission (AIE) characteristics of the TPE core, TPE-TPP possesses high specificity to mitochondria, superior…
Citation impact
- FWCI
- 24.91
- Percentile
- 100%
- References
- 20
Authors
6- CWChris Wai Tung LeungCorresponding
Hong Kong University of Science and Technology, Institute of Molecular Functional Materials
- YHYuning Hong
Hong Kong University of Science and Technology, Institute of Molecular Functional Materials
- SCSijie Chen
Hong Kong University of Science and Technology, Institute of Molecular Functional Materials
- EZEngui Zhao
Hong Kong University of Science and Technology, Institute of Molecular Functional Materials
- JWJacky W. Y. Lam
Hong Kong University of Science and Technology, Institute of Molecular Functional Materials
Topics & keywords
- Chemistry
- Mitochondrion
- Aggregation-induced emission
- Fluorescence
- Biophysics
- Apoptosis
- Fluorescence-lifetime imaging microscopy
- Cell biology