Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention

BackgroundAtopic dermatitis (atopic eczema) is a chronic inflammatory skin disease that has reached epidemic proportions in children worldwide and is increasing in prevalence. Because of the significant socioeconomic effect of atopic dermatitis and its effect on the quality of life of children and families, there have been decades of research focused on disease prevention, with limited success. Recent advances in cutaneous biology suggest skin barrier defects might be key initiators of atopic dermatitis and possibly allergic sensitization.ObjectiveOur objective was to test whether skin barrier enhancement from birth represents a feasible strategy for reducing the incidence of atopic dermatitis in high-risk…

• AA
  American Academy of Allergy Asthma and Immunology
• G
  GlaxoSmithKline
• WT
  Wellcome Trust

  Awards: 5K23AR057486, RP-PG-0407-10177, 098439/Z/12/Z, RPPG-0407-10177, 092530/Z/10/Z, 5 KL2 RR024141-04
• NI
  National Institute for Health and Care Research

  Awards: 5K23AR057486, RPPG-0407-10177, 098439/Z/12/Z, 5 KL2 RR024141-04, RP-PG-0407-10177, 092530/Z/10/Z
• AP
  Astellas Pharma
• NI
  National Institutes of Health

  Awards: 092530/Z/10/Z, 5 KL2 RR024141-04, RP-PG-0407-10177, RPPG-0407-10177, 098439/Z/12/Z, 5K23AR057486
• OC
  Oregon Clinical and Translational Research Institute

  Awards: 5K23AR057486, 098439/Z/12/Z, RPPG-0407-10177, 092530/Z/10/Z, RP-PG-0407-10177, 5 KL2 RR024141-04
• PG
  Programme Grants for Applied Research
• NI
  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  Awards: 5K23AR057486, 098439/Z/12/Z, 5 KL2 RR024141-04, RPPG-0407-10177, 092530/Z/10/Z, RP-PG-0407-10177
• NC
  National Center for Research Resources

  Awards: 5K23AR057486, RP-PG-0407-10177, 092530/Z/10/Z, 5 KL2 RR024141-04, KL2 RR024141, 098439/Z/12/Z, RPPG-0407-10177