Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7
Garvan Institute of Medical Research · Victor Chang Cardiac Research Institute · +4 more institutions
Abstract
Chemotactic cytokines (chemokines) attract immune cells, although their original evolutionary role may relate more closely with embryonic development. We noted differential expression of the chemokine receptor CXCR7 (RDC-1) on marginal zone B cells, a cell type associated with autoimmune diseases. We generated Cxcr7(-/-) mice but found that CXCR7 deficiency had little effect on B cell composition. However, most Cxcr7(-/-) mice died at birth with ventricular septal defects and semilunar heart valve malformation. Conditional deletion of Cxcr7 in endothelium, using Tie2-Cre transgenic mice, recapitulated this phenotype. Gene profiling of Cxcr7(-/-) heart valve leaflets revealed a defect in the expression of…
Citation impact
- FWCI
- 18.53
- Percentile
- 100%
- References
- 47
Authors
14- FSFrédéric SierroCorresponding
Garvan Institute of Medical Research
- CBChristine Biben
Victor Chang Cardiac Research Institute
- LMLaura Martínez‐Muñoz
Columbia University Irving Medical Center, Centro Nacional de Biotecnología, New York University
- MMMario Mellado
Centro Nacional de Biotecnología
- RMRichard M. Ransohoff
Cleveland Clinic
Topics & keywords
- Biology
- Cell biology
- Chemokine
- CXCR4
- Chemokine receptor
- Haematopoiesis
- Receptor
- Phenotype
- Good health and well-being