Resolvin D1 binds human phagocytes with evidence for proresolving receptors
Brigham and Women's Hospital · Harvard University · +1 more institution
Abstract
Endogenous mechanisms that act in the resolution of acute inflammation are essential for host defense and the return to homeostasis. Resolvin D1 (RvD1), biosynthesized during resolution, displays potent and stereoselective anti-inflammatory actions, such as limiting neutrophil infiltration and proresolving actions. Here, we demonstrate that RvD1 actions on human polymorphonuclear leukocytes (PMNs) are pertussis toxin sensitive, decrease actin polymerization, and block LTB(4)-regulated adhesion molecules (beta2 integrins). Synthetic [(3)H]-RvD1 was prepared, which revealed specific RvD1 recognition sites on human leukocytes. Screening systems to identify receptors for RvD1 gave two candidates--ALX, a lipoxin…
Citation impact
- FWCI
- 18.23
- Percentile
- 100%
- References
- 36
Authors
8- SKSriram KrishnamoorthyCorresponding
Brigham and Women's Hospital, Harvard University
- ARAntonio Recchiuti
Brigham and Women's Hospital, Harvard University
- NCNan Chiang
Brigham and Women's Hospital, Harvard University
- SYStephanie Yacoubian
Brigham and Women's Hospital, Harvard University
- CLChih‐Hao Lee
Harvard University
Topics & keywords
- Receptor
- Cell biology
- Inflammation
- Pertussis toxin
- Orphan receptor
- Chemistry
- Phagocytosis
- Zymosan