Decreased extra-renal urate excretion is a common cause of hyperuricemia

Ichida, Kimiyoshi; Matsuo, Hirotaka; Takada, Tappei; Nakayama, Akiyoshi; Murakami, Keizo; Shimizu, Toru; Yamanashi, Yoshihide; Kasuga, Hiroshi; Nakashima, Hiroshi; Nakamura, Takahiro; Takada, Yuzo; Kawamura, Yusuke; Inoue, Hiroki; Okada, Chisa; Utsumi, Yoshitaka; Ikebuchi, Yuki; Ito, Kousei; Nakamura, Makiko; Shinohara, Yoshihiko; Hosoyamada, Makoto; Sakurai, Yutaka; Shinomiya, Nariyoshi; Hosoya, Tatsuo; Suzuki, Hiroshi

doi:10.1038/ncomms1756

articleNature CommunicationsApr 3, 2012HYBRID OA

Decreased extra-renal urate excretion is a common cause of hyperuricemia

KIKimiyoshi Ichida HMHirotaka Matsuo TTTappei Takada ANAkiyoshi Nakayama KMKeizo Murakami

Tokyo University of Pharmacy and Life Sciences · National Defense Medical College · +6 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

ABCG2, also known as BCRP, is a high-capacity urate exporter, the dysfunction of which raises gout/hyperuricemia risk. Generally, hyperuricemia has been classified into urate 'overproduction type' and/or 'underexcretion type' based solely on renal urate excretion, without considering an extra-renal pathway. Here we show that decreased extra-renal urate excretion caused by ABCG2 dysfunction is a common mechanism of hyperuricemia. Clinical parameters, including urinary urate excretion, are examined in 644 male outpatients with hyperuricemia. Paradoxically, ABCG2 export dysfunction significantly increases urinary urate excretion and risk ratio of urate overproduction. Abcg2-knockout mice show increased serum uric…

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Topics & keywords

Topics

Keywords

Hyperuricemia
Gout
Internal medicine
Endocrinology
Excretion
Uric acid
Medicine
Tamm–Horsfall protein

UN Sustainable Development Goals

Good health and well-being

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