reviewClinica Chimica ActaJun 16, 2013HYBRID OA

Foam cells in atherosclerosis

XYXiao-Hua YuYFYuchang FuDZDawei ZhangKYKai YinCTChao‐Ke Tang

University of South China · University of Alabama at Birmingham · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

Atherosclerosis is a chronic disease characterized by the deposition of excessive cholesterol in the arterial intima. Macrophage foam cells play a critical role in the occurrence and development of atherosclerosis. The generation of these cells is associated with imbalance of cholesterol influx, esterification and efflux. CD36 and scavenger receptor class A (SR-A) are mainly responsible for uptake of lipoprotein-derived cholesterol by macrophages. Acyl coenzyme A:cholesterol acyltransferase-1 (ACAT1) and neutral cholesteryl ester hydrolase (nCEH) regulate cholesterol esterification. ATP-binding cassette transporters A1(ABCA1), ABCG1 and scavenger receptor BI (SR-BI) play crucial roles in macrophage cholesterol…

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767
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30.45
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100%
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89
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Authors

5

Topics & keywords

Topics
Keywords
  • Scavenger receptor
  • Foam cell
  • ABCA1
  • Cholesterol
  • CD36
  • Reverse cholesterol transport
  • Cholesteryl ester
  • Sterol O-acyltransferase
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