Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma
University of Würzburg · Robert Bosch Hospital · +5 more institutions
Abstract
Diffuse large B cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma. In the least curable (ABC) subtype of DLBCL, survival of the malignant cells is dependent on constitutive activation of the nuclear factor-kappaB (NF-kappaB) signaling pathway. In normal B cells, antigen receptor-induced NF-kappaB activation requires CARD11, a cytoplasmic scaffolding protein. To determine whether CARD11 contributes to tumorigenesis, we sequenced the CARD11 gene in human DLBCL tumors. We detected missense mutations in 7 of 73 ABC DLBCL biopsies (9.6%), all within exons encoding the coiled-coil domain. Experimental introduction of CARD11 coiled-coil domain mutants into lymphoma cell lines resulted in…
Citation impact
- FWCI
- 24.86
- Percentile
- 100%
- References
- 24
Authors
22- GLGeorg LenzCorresponding
University of Würzburg, Robert Bosch Hospital, Omeros Corporation (United States), National Cancer Institute, National Cancer Institute, Center for Cancer Research
- RER. Eric DavisCorresponding
University of Würzburg, Robert Bosch Hospital, Omeros Corporation (United States), National Cancer Institute, National Cancer Institute, Center for Cancer Research
- VNVu N. Ngo
University of Würzburg, Robert Bosch Hospital, Omeros Corporation (United States), National Cancer Institute, National Cancer Institute, Center for Cancer Research
- LTLloyd T. Lam
University of Würzburg, Robert Bosch Hospital, Omeros Corporation (United States), National Cancer Institute, National Cancer Institute, Center for Cancer Research
- TCThaddeus C. George
University of Würzburg, Robert Bosch Hospital, Omeros Corporation (United States), National Cancer Institute, National Cancer Institute, Center for Cancer Research
Topics & keywords
- Diffuse large B-cell lymphoma
- Cancer research
- Lymphoma
- BCL10
- Biology
- Carcinogenesis
- Missense mutation
- Mutation
- Good health and well-being