articleAmerican Journal of Respiratory and Critical Care MedicineApr 30, 2013Closed access

Evolution of Mortality over Time in Patients Receiving Mechanical Ventilation

AEAndrés EstebanFFFernando Frutos–VivarAMAlfonso MurielNDNiall D. FergusonÓPÓscar Peñuelas

Centro de Investigación Biomédica en Red de Enfermedades Respiratorias · Hospital Universitario de Getafe · +36 more institutions

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Abstract

Objectives

To estimate whether mortality in mechanically ventilated patients has changed over time.

Methods

Prospective cohort studies conducted in 1998, 2004, and 2010, including patients receiving mechanical ventilation for more than 12 hours in a 1-month period, from 927 units in 40 countries. To examine effects over time on mortality in intensive care units, we performed generalized estimating equation models. MEASUREMENTS AND MAIN RESULTS: We included 18,302 patients. The reasons for initiating mechanical ventilation varied significantly among cohorts. Ventilatory management changed over time (P

Citation impact

685
total citations
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41.39
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100%
References
44
Citations per year

Authors

36

Topics & keywords

Topics
Keywords
  • Medicine
  • Mechanical ventilation
  • Confidence interval
  • Odds ratio
  • Intensive care unit
  • Ventilation (architecture)
  • Tidal volume
  • Intensive care
UN Sustainable Development Goals
  • Good health and well-being
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