Metabolic Reconstruction for Metagenomic Data and Its Application to the Human Microbiome 
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Microbial communities carry out the majority of the biochemical activity on the planet, and they play integral roles in processes including metabolism and immune homeostasis in the human microbiome. Shotgun sequencing of such 
\ncommunities’ metagenomes provides information complementary to organismal abundances from taxonomic markers, but the resulting data typically comprise short reads from hundreds of different organisms and are at best challenging to assemble comparably to single-organism genomes. Here, we describe an alternative approach to infer the functional and 
\nmetabolic potential of a microbial community metagenome. We determined the gene families and pathways present or absent within a…