Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors

Translational studies in liver transplantation often require an endpoint of graft function or dysfunction beyond graft loss. Prior definitions of early allograft dysfunction (EAD) vary, and none have been validated in a large multicenter population in the Model for End-Stage Liver Disease (MELD) era. We examined an updated definition of EAD to validate previously used criteria, and correlated this definition with graft and patient outcome. We performed a cohort study of 300 deceased donor liver transplants at 3 U.S. programs. EAD was defined as the presence of one or more of the following previously defined postoperative laboratory analyses reflective of liver injury and function: bilirubin >or=10mg/dL on day…

• NI
  National Institutes of Health
• NI
  National Institute of Allergy and Infectious Diseases
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Award: 5-U01-AI-063589-05