articleStem CellsMar 30, 2007BRONZE OA

The In Vitro Migration Capacity of Human Bone Marrow Mesenchymal Stem Cells: Comparison of Chemokine and Growth Factor Chemotactic Activities

ALAdriana López PonteEMEmeline MaraisNGNathalie GallayALAlain LangonnéBDBruno Delorme

Inserm · Université de Tours · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Adult bone marrow (BM)-derived stem cells, including hematopoietic stem cells (HSCs) and MSCs, represent an important source of cells for the repair of a number of damaged tissues. In contrast to HSCs, the soluble factors able to induce MSC migration have not been extensively studied. In the present work, we compared the in vitro migration capacity of human BM-derived MSCs, preincubated or not with the inflammatory cytokines interleukin 1beta (IL1beta) and tumor necrosis factor alpha (TNFalpha), in response to 16 growth factors (GFs) and chemokines. We show that BM MSCs migrate in response to many chemotactic factors. The GFs platelet-derived growth factor-AB (PDGF-AB) and insulin-like growth factor 1 (IGF-1)…

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Topics & keywords

Topics
Keywords
  • Biology
  • Cell biology
  • Stem cell factor
  • Mesenchymal stem cell
  • Chemokine receptor
  • Stem cell
  • Chemokine
  • Cancer research
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