Genome Sequence, Comparative Analysis, and Population Genetics of the Domestic Horse
Broad Institute · The University of Sydney · +30 more institutions
Abstract
We report a high-quality draft sequence of the genome of the horse (Equus caballus). The genome is relatively repetitive but has little segmental duplication. Chromosomes appear to have undergone few historical rearrangements: 53% of equine chromosomes show conserved synteny to a single human chromosome. Equine chromosome 11 is shown to have an evolutionary new centromere devoid of centromeric satellite DNA, suggesting that centromeric function may arise before satellite repeat accumulation. Linkage disequilibrium, showing the influences of early domestication of large herds of female horses, is intermediate in length between dog and human, and there is long-range haplotype sharing among breeds.
Citation impact
- FWCI
- 31.98
- Percentile
- 100%
- References
- 17
Authors
58Topics & keywords
- Equus
- Biology
- Domestication
- Genetics
- Evolutionary biology
- Horse
- Centromere
- Genome
Funding
- UDU.S. Department of DefenseAwards: W81XWH-19-1-0668, W81XWH, W81XWH-18-1-0440, W81XWH-18-1-0404, W81XWH-20-1-0595, W81XWH-18
- UDU.S. Department of Veterans AffairsAward: IBX004121A
- CRCancer Research InstituteAward: 18/SPP/3522
- BCBreast Cancer Research FoundationAwards: CCRC13GAL, 17-194, CA116201
- BSBristol-Myers Squibb
- ELEli Lilly and Company
- AAstraZenecaAward: 18/SPP/3522
- GSGilead Sciences
- SGSusan G. Komen
- IRIrish Research eLibrary
- CRCancer Research UKAwards: CRUK/07/012, C45982/A21808, A21808, CA116201
- ECEuropean CommissionAwards: 860627, CA116201
- NBNational Breast Cancer FoundationAwards: CA116201, EC-17-001
- HEHigher Education Authority
- ICIrish Cancer SocietyAward: CCRC13GAL
- SFScience Foundation IrelandAwards: 18/SPP/3522, 15/IA/3104, 15/IA/
- ANAgence Nationale de la RechercheAwards: 17-CONV-0005, ANR-19-P3IA-0001, 19-P3IA-0001, ANR-17, ANR-17-CONV-0005, ANR-19, CA116201
- MVMinisterie van Volksgezondheid, Welzijn en Sport
- SSSvenska Sällskapet för Medicinsk Forskning
- KLKU Leuven
- FAFondation ARC pour la Recherche sur le Cancer
- LCLigue Contre le CancerAward: CA116201
- PMPeter MacCallum Cancer CentreAwards: UH3CA225021, U24CA215109
- KKKWF KankerbestrijdingAward: CA116201
- NINational Institutes of HealthAwards: P50 CA116201, R01CA202752, 1U01CA239055-01, R01CA216579-01A1, R01CA202752-01A1, CA116201, CA225655, 1U54CA254566-01, P50 CA247749 01, -0001, R01CA220581-01A1, R01CA208236-01A1, W81XWH, CA263705, DK124165, CA224319, P50 CA247749, CA196521, R37 CA225655
- MRMedical Research CouncilAward: CA116201
- EAEngineering and Physical Sciences Research CouncilAward: EP/W02909X/1
- NHNational Health and Medical Research CouncilAwards: 1162318, GNT1193630
- JSJapan Society for the Promotion of ScienceAwards: 21K06909, 21-102
- NCNational Cancer InstituteAwards: R01CA216579-01A1, P50 CA247749 01, U24CA215109, P50 CA116201, P50 CA247749, R01CA249992, R01CA257612-01A1, R37 CA225655, CA247749, R01CA220581, 1U54CA254566-01, CA116201, 1U01CA239055-01, R01CA208236, R01CA216579, R01CA202752, R01CA26820701A1, R01CA257612, UH3CA225021, CA196521, R01CA249992-01A1, DK124165, R01CA220581-01A1, U01CA269181, R01CA202752-01A1, R01CA208236-01A1, R01CA268287A1, CA224319
- DPDOD Prostate Cancer Research ProgramAwards: W81XWH-21-1-0160, W81XWH-20-1-0851
- DPDOD Peer Reviewed Cancer Research ProgramAwards: W81XWH-21-1-0160, W81XWH-18-1-0440, W81XWH-21-1-0345, W81XWH-18-1-0404