Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function
Chinese Academy of Sciences · Beijing Institute of Genomics · +5 more institutions
Abstract
Exosomes are 40-100 nm nano-sized vesicles that are released from many cell types into the extracellular space. Such vesicles are widely distributed in various body fluids. Recently, mRNAs and microRNAs (miRNAs) have been identified in exosomes, which can be taken up by neighboring or distant cells and subsequently modulate recipient cells. This suggests an active sorting mechanism of exosomal miRNAs, since the miRNA profiles of exosomes may differ from those of the parent cells. Exosomal miRNAs play an important role in disease progression, and can stimulate angiogenesis and facilitate metastasis in cancers. In this review, we will introduce the origin and the trafficking of exosomes between cells, display…
Citation impact
- FWCI
- 57.67
- Percentile
- 100%
- References
- 86
Authors
7- JZJian Zhang
Chinese Academy of Sciences, Beijing Institute of Genomics, University of Chinese Academy of Sciences
- SLSha Li
Chinese Academy of Sciences, Beijing Institute of Genomics, University of Chinese Academy of Sciences
- LLLu Li
Shandong University, Jinan Central Hospital
- MLMeng Li
Chinese Academy of Sciences, Beijing Institute of Genomics
- CGChongye Guo
Chinese Academy of Sciences, Beijing Institute of Genomics
Topics & keywords
- Microvesicles
- microRNA
- Exosome
- Cell biology
- Extracellular vesicles
- Biology
- Angiogenesis
- Cell sorting