Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41
Howard Hughes Medical Institute · Japan Science and Technology Agency · +2 more institutions
Abstract
Leptin is an adipose-derived hormone that regulates a wide variety of physiological processes, including feeding behavior, metabolic rate, sympathetic nerve activity, reproduction, and immune response. Circulating leptin levels are tightly regulated according to energy homeostasis in vivo. Although mechanisms for the regulation of leptin production in adipocytes are not well understood, G protein-coupled receptors may play an important role in this adipocyte function. Here we report that C2-C6 short-chain fatty acids, ligands of an orphan G protein-coupled receptor GPR41, stimulate leptin expression in both a mouse adipocyte cell line and mouse adipose tissue in primary culture. Acute oral administration of…
Citation impact
- FWCI
- 3.64
- Percentile
- 100%
- References
- 40
Authors
7- YXYumei XiongCorresponding
Howard Hughes Medical Institute, Japan Science and Technology Agency, Southwestern Medical Center, The University of Texas Southwestern Medical Center
- NMNorimasa Miyamoto
Howard Hughes Medical Institute, Japan Science and Technology Agency, Southwestern Medical Center, The University of Texas Southwestern Medical Center
- KSKenji Shibata
Howard Hughes Medical Institute, Japan Science and Technology Agency, Southwestern Medical Center, The University of Texas Southwestern Medical Center
- MAMark A. Valasek
Howard Hughes Medical Institute, Japan Science and Technology Agency, Southwestern Medical Center, The University of Texas Southwestern Medical Center
- TMToshiyuki Motoike
Howard Hughes Medical Institute, Japan Science and Technology Agency, Southwestern Medical Center, The University of Texas Southwestern Medical Center
Topics & keywords
- Leptin
- Adipose tissue
- Leptin receptor
- Endocrinology
- Internal medicine
- Adipocyte
- Energy homeostasis
- Adipokine