The Redox Code

SIGNIFICANCE: The redox code is a set of principles that defines the positioning of the nicotinamide adenine dinucleotide (NAD, NADP) and thiol/disulfide and other redox systems as well as the thiol redox proteome in space and time in biological systems. The code is richly elaborated in an oxygen-dependent life, where activation/deactivation cycles involving O₂ and H₂O₂ contribute to spatiotemporal organization for differentiation, development, and adaptation to the environment. Disruption of this organizational structure during oxidative stress represents a fundamental mechanism in system failure and disease. RECENT ADVANCES: Methodology in assessing components of the redox code under physiological conditions…

• NF
  National Foundation for Cancer Research
• DF
  Deutsche Forschungsgemeinschaft
• NI
  National Institutes of Health

  Awards: ES009047, HL113451, AG038746, ES019776, ES023485