Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre
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Abstract
NMO-IgG is a disease-specific autoantibody for neuromyelitis optica (NMO) and its target antigen is aquaporin-4 (AQP4) water channel. Recently, we established a sensitive anti-AQP4 antibody assay using human AQP4-transfected cells, which appeared more sensitive than the original NMO-IgG assay. So far, there has been no large-scale study on anti-AQP4 antibody titre in NMO and related disorders. We tested 148 sera of patients with NMO, high-risk syndrome of NMO, multiple sclerosis (MS), clinically isolated syndrome suggestive of MS and miscellaneous diseases. We analysed the relation of anti-AQP4 antibody titres and clinical and laboratory parameters. The sensitivity of anti-AQP4 antibody assay was 91% (95% CI…
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Authors
12Topics & keywords
Topics
Keywords
- Neuromyelitis optica
- Antibody
- Medicine
- Autoantibody
- Aquaporin 4
- Multiple sclerosis
- Immunology
- Titer
UN Sustainable Development Goals
- Clean water and sanitation
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