Exercise and IL‐6 infusion inhibit endotoxin‐induced TNF‐α production in humans
University of Copenhagen · Copenhagen University Hospital · +1 more institution
Abstract
During "nondamaging" exercise, skeletal muscle markedly releases interleukin (IL)-6, and it has been suggested that one biological role of this phenomenon is to inhibit the production of tumor necrosis factor (TNF)- alpha, which is known to cause pathogenesis such as insulin resistance and atherosclerosis. To test this hypothesis, we performed three experiments in which eight healthy males either rested (CON), rode a bicycle for 3 h (EX), or were infused with recombinant human IL-6 (rhIL-6) for 3 h while they rested. After 2.5 h, the volunteers received a bolus of Escherichia coli lipopolysaccharide endotoxin (0.06 ng/kg) i.v. to induce low-grade inflammation. In CON, plasma TNF-alpha increased significantly…
Citation impact
- FWCI
- 21.60
- Percentile
- 100%
- References
- 23
Authors
5- RLRebecca L. StarkieCorresponding
University of Copenhagen, Copenhagen University Hospital, Rigshospitalet
- SRSisse Rye Ostrowski
University of Copenhagen
- SJSune Jauffred
University of Copenhagen, Copenhagen University Hospital, Rigshospitalet
- MAMark A. Febbraio
University of Copenhagen, Copenhagen University Hospital, Rigshospitalet
- BKBente Klarlund Pedersen
University of Copenhagen, Copenhagen University Hospital, Rigshospitalet
Topics & keywords
- Tumor necrosis factor alpha
- Lipopolysaccharide
- Pathogenesis
- Inflammation
- Medicine
- Endocrinology
- Bolus (digestion)
- Internal medicine
- Good health and well-being