reviewMediators of InflammationJan 1, 2014GOLD OA

Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity

GOGabriel OlmosJLJerònia Lladó

Servei de Salut de les Illes Balears · Research Institute of Health Sciences · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Tumor necrosis factor alpha (TNF- α) is a proinflammatory cytokine that exerts both homeostatic and pathophysiological roles in the central nervous system. In pathological conditions, microglia release large amounts of TNF-α; this de novo production of TNF-α is an important component of the so-called neuroinflammatory response that is associated with several neurological disorders. In addition, TNF-α can potentiate glutamate-mediated cytotoxicity by two complementary mechanisms: indirectly, by inhibiting glutamate transport on astrocytes, and directly, by rapidly triggering the surface expression of Ca(+2) permeable-AMPA receptors and NMDA receptors, while decreasing inhibitory GABAA receptors on neurons.…

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701
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26.07
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100%
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Authors

2

Topics & keywords

Topics
Keywords
  • Neuroinflammation
  • Excitotoxicity
  • Neuroscience
  • Tumor necrosis factor alpha
  • Proinflammatory cytokine
  • Glutamate receptor
  • Microglia
  • AMPA receptor
UN Sustainable Development Goals
  • Good health and well-being
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