Rapid evolution of the neutralizing antibody response to HIV type 1 infection

A recombinant virus assay was used to characterize in detail neutralizing antibody responses directed at circulating autologous HIV in plasma. Examining serial plasma specimens in a matrix format, most patients with primary HIV infection rapidly generated significant neutralizing antibody responses to early (0-39 months) autologous viruses, whereas responses to laboratory and heterologous primary strains were often lower and delayed. Plasma virus continually and rapidly evolved to escape neutralization, indicating that neutralizing antibody exerts a level of selective pressure that has been underappreciated based on earlier, less comprehensive characterizations. These data argue that neutralizing antibody…

• UD
  U.S. Department of Veterans Affairs
• SB
  Small Business Innovation Research
• NI
  National Institutes of Health
• CF
  Center for AIDS Research, University of Washington