Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak

<div><h3>Background</h3><p>A chikungunya virus outbreak of unprecedented magnitude is currently ongoing in Indian Ocean territories. In Réunion Island, this alphavirus has already infected about one-third of the human population. The main clinical symptom of the disease is a painful and invalidating poly-arthralgia. Besides the arthralgic form, 123 patients with a confirmed chikungunya infection have developed severe clinical signs, i.e., neurological signs or fulminant hepatitis.</p> <h3>Methods and Findings</h3><p>We report the nearly complete genome sequence of six selected viral isolates (isolated from five sera and one cerebrospinal fluid), along with…

• CN
  Centre National de la Recherche Scientifique
• ID
  Institut de Veille Sanitaire