Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis
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Abstract
Objective
To assess the magnitude and direction of associations of depression with C-reactive protein (CRP), interleukin (IL)-1, and IL-6 in community and clinical samples.
Methods
Systematic review of articles published between January 1967 and January 2008 in the PubMed and PsycINFO electronic databases was performed. Effect sizes were calculated as stat d and meta-analyzed, using random-effects models.
Results
Each inflammatory marker was positively associated with depression; CRP, d = 0.15 (95% CI = 0.10, 0.21), p
Citation impact
2,750
total citations
- FWCI
- 34.47
- Percentile
- 100%
- References
- 173
Citations per year
Authors
3Topics & keywords
Topics
Keywords
- Depression (economics)
- Internal medicine
- C-reactive protein
- Medicine
- PsycINFO
- Body mass index
- Meta-analysis
- Inflammation
UN Sustainable Development Goals
- Good health and well-being
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