Hydrogen sulfide is an endogenous stimulator of angiogenesis

Papapetropoulos, Andreas; Pyriochou, Anastasia; Altaany, Zaid; Yang, Guangdong; Marazioti, Antonia; Zhou, Zongmin; Jeschke, Mark G.; Branski, Ludwik K.; Herndon, David N.; Wang, Rui; Szabó, Csaba

doi:10.1073/pnas.0908047106

articleProceedings of the National Academy of SciencesDec 3, 2009GREEN OA

Hydrogen sulfide is an endogenous stimulator of angiogenesis

APAndreas Papapetropoulos APAnastasia Pyriochou ZAZaid Altaany GYGuangdong Yang AMAntonia Marazioti

University of Patras · Lakehead University · +4 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

The goal of the current study was to investigate the role of exogenous and endogenous hydrogen sulfide (H(2)S) on neovascularization and wound healing in vitro and in vivo. Incubation of endothelial cells (ECs) with H(2)S enhanced their angiogenic potential, evidenced by accelerated cell growth, migration, and capillary morphogenesis on Matrigel. Treatment of chicken chorioallantoic membranes (CAMS) with H(2)S increased vascular length. Exposure of ECs to H(2)S resulted in increased phosphorylation of Akt, ERK, and p38. The K(ATP) channel blocker glibenclamide or the p38 inhibitor SB203580 abolished H(2)S-induced EC motility. Since glibenclamide inhibited H(2)S-triggered p38 phosphorylation, we propose that…

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Keywords

Angiogenesis
Matrigel
Chemistry
Protein kinase B
Neovascularization
Vascular endothelial growth factor
Cell biology
In vivo

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