Characterization of Gut Microbiomes in Nonalcoholic Steatohepatitis (NASH) Patients: A Connection Between Endogenous Alcohol and NASH
Buffalo State University · University at Buffalo, State University of New York · +2 more institutions
Abstract
UNLABELLED: Nonalcoholic steatohepatitis (NASH) is a serious liver disease associated with obesity. Characterized by metabolic syndrome, hepatic steatosis, and liver inflammation, NASH is believed to be under the influence of the gut microflora. Here, the composition of gut bacterial communities of NASH, obese, and healthy children was determined by 16S ribosomal RNA pyrosequencing. In addition, peripheral blood ethanol was analyzed to monitor endogenous ethanol production of patients and healthy controls. UniFrac-based principle coordinates analysis indicated that most of the microbiome samples clustered by disease status. Each group was associated with a unique pattern of enterotypes. Differences were…
Citation impact
- FWCI
- 30.10
- Percentile
- 100%
- References
- 57
Authors
7- LZLixin Zhu
Buffalo State University, University at Buffalo, State University of New York
- SSSusan S. BakerCorresponding
GTx (United States), University at Buffalo, State University of New York
- CGChelsea Gill
University of Rochester
- WLWensheng Liu
University at Buffalo, State University of New York
- RARazan Alkhouri
University at Buffalo, State University of New York
Topics & keywords
- Microbiome
- Steatohepatitis
- Biology
- Nonalcoholic steatohepatitis
- Nonalcoholic fatty liver disease
- Gut flora
- Internal medicine
- Fatty liver
- Good health and well-being