Cholangiocarcinoma

Cholangiocarcinoma (CCA) is an epithelial cancer originating from the bile ducts with features of cholangiocyte differentiation.1 CCA is the second most common primary hepatic malignancy, and epidemiologic studies suggest its incidence is increasing in Western countries.2 Advanced CCA has a devastating prognosis, with a median survival of 65 years, and it is only rarely diagnosed in patients 90% of cancers.33, 34 Thus, despite shared developmental ontology between the pancreatic ducts and the biliary tree, their adult cancers are different. Nuclear accumulation of p53 and up-regulation of the related protein mdm-2 and WAF-1 have been reported in 21.7% to 76% of CCAs.35-42 Other inactivated tumor suppressor…

• MC
  Mayo Clinic
• MF
  Mayo Foundation for Medical Education and Research
• NI
  National Institutes of Health

  Award: DK59427