Survival in Infection-Related Acute-on-Chronic Liver Failure Is Defined by Extrahepatic Organ Failures
Virginia Commonwealth University · Hunter Holmes McGuire VA Medical Center · +11 more institutions
Abstract
UNLABELLED: Infections worsen survival in cirrhosis; however, simple predictors of survival in infection-related acute-on-chronic liver failure (I-ACLF) derived from multicenter studies are required in order to improve prognostication and resource allocation. Using the North American Consortium for Study of End-stage Liver Disease (NACSELD) database, data from 18 centers were collected for survival analysis of prospectively enrolled cirrhosis patients hospitalized with an infection. We defined organ failures as 1) shock, 2) grade III/IV hepatic encephalopathy (HE), 3) need for dialysis and mechanical ventilation. Determinants of survival with these organ failures were analyzed. In all, 507 patients were…
Citation impact
- FWCI
- 14.49
- Percentile
- 100%
- References
- 20
Authors
13Topics & keywords
- Medicine
- Liver failure
- Internal medicine
- Intensive care medicine
- Gastroenterology